Endocrine Abstracts

Hyperandrogenism is a clinical condition characterized by excessive secretion of male sex hormones. An excess amount of androgens in women is manifested by symptoms of defeminization and masculinization. Hormonally active adrenal and ovarian tumors and non-tumor causes must be considered in the differential diagnosis. The authors describe the case of a 77-year-old patient who had hirsutism and reduction of the timbre of the voice. At the beginning she was suspected to have adr...

Introduction: The aim of our study was to assess the value of blood pressure and heart rate using the 24-h blood pressure monitoring (ABPM) before and after treatment with metformin to patients with polycystic ovary syndrome (PCOS) and normal lean.Material and methods: 20 patients received metformin 1500 mg/day in three divided doses. ABPM was performed to each patient with PCOS twice: before and after 6 months of treatment with metformin.<p class="a...

Background: Despite the strong preclinical rationale, there are only very few data considered the utility of metformin, as a potential pain therapeutic in humans. The aim of this study was to determine, the association between metformin therapy and pressure pain threshold (PPT) in lean polycystic ovary syndrome (PCOS) women. We hypothesized that metformin therapy in lean PCOS women increases pressure pain threshold.Materials and methods: Twenty-seven lea...

We present a case of a eighteen-year-old woman admitted to the Gynecological and Endocrinological Department because of primary amenorrhea. Physical examination showed excessive pubic hair and clitoral hypertrophy. Laboratory tests showed the increased level of foliculotropina (FSH) 90 mIU/ml (normal range 3.5–12.5 mIU/ml) and the estradiol level below 10 pmol/l (normal range 46–607 pmol/l). An ultrasound-imaging of the abdomen and pelvis showed the uterus of normal ...

Introduction: The aim of our study was to assess the values of total cholesterol, HDL-C, LDL-C and triglycerides before and after treatment with metformin in patients with polycystic ovary syndrome (PCOS) and normal lean.Material and methods: 32 patients received metformin 1500 mg/day in three divided doses. Lipids measurements were performed to each patient with PCOS twice: before and after 6 months of treatment with metformin.Res...

: Hyperinsulinemia is one of biochemical features of polycystic ovary syndrome (PCOS). Metformin is a common drug used in PCOS. Recent studies have shown that metformin has impact on clinical and biochemical parameters in PCOS patients. The aim of our study was to assess retrospectively the influence of metformin on total testosterone, sex hormone binding globulin (SHBG) and free androgen index (FAI) in women with PCOS in polish cohort. A total of 54 patients with PCOS and irr...

Introduction: The aim of our study was to assess the morning and evening cortisol plasma levels in women with polycystic ovary syndrome (PCOS).Material and method: 95 patients gave their informed consent to participate in the study and were divided into two groups. Group A consisted of 40 PCOS patients and group B consisted of 55 women without features of PCOS. Between day 5 and 8 of the menstrual cycle, morning (0700 h), fasting blood samples were taken...

Aim: Aim of our study was to compare: the baseline and metoclopramide induced prolactin plasma level between PCOS women with FAI <5 phenotype (group A)(FAI, total testosterone divided by sex hormone biding globulin, whole multiply by 100) and PCOS women with FAI>5 phenotype (group B).Patients and methods: The study population consisted of 354 lean women with PCOS. In all the patients the prolactin level at 02:00 h, 08:00 h and during the metoclop...

Aim: Evaluation of pressure pain threshold and β-endorphin plasma level in lean women with polycystic ovary syndrome (PCOS) and healthy controls. The associations between β- endorphins and pressure pain threshold were also investigated.Materials and methods: In 48 lean women with polycystic ovary syndrome and 38 lean women without this disorder plasma β-endorphins and pressure pain thresholds were measured.Results: T...

Introduction: Polycystic ovary syndrome (PCOS) is one of the most common causes of anovulatory and infertility. According to the widespread data it affects 3–10% of women in the procreative age. Although many research have been done, it is still unclear which of mechanisms are responsible for the development of PCOS. The most up-to-date scientific trial indicates that the evolution of PCOS is related to the activity of the endogenous opioid system but precise mechanism is...